Vitamin D helps the intestines absorb calcium. However, the vitamin D must first be activated or "turned on" by parathyroid hormone (PTH). Once activated. How important are vitamin D and the parathyroid hormone to cardiovascular health? relationship between vitamin D deficiency and elevated parathyroid As vitamin D deficiency and elevated parathyroid hormone levels. An inverse relationship between serum hydroxyvitamin D and serum parathyroid hormone (PTH) is well established, up to a certain level of.
They were administered a semi-quantitative food frequency questionnaire, which assessed vitamin D and calcium intake. Vitamin D supplements are necessary for adequate vitamin D status in northern climates.
The importance of adequate vitamin D status for optimum bone health has received increased recognition in recent years, with higher recommended intake levels being proposed by some investigators.
Serum hydroxyvitamin D has been the generally accepted indicator of vitamin D status, but no universal consensus has been reached regarding which serum values constitute sufficiency. An inverse relationship between serum hydroxyvitamin D and serum parathyroid hormone PTH is well established, up to a certain level of hydroxyvitamin D, in which little further decrease in serum PTH is observed.
The serum level for hydroxyvitamin D corresponding with the PTH inflection point has been interpreted as indicative of optimal calcium homeostasis and proposed as a marker of vitamin D sufficiency.
The goal of our study was to investigate the relative importance of high calcium intake and serum hydroxyvitamin D for calcium homeostasis in healthy adults, as determined by serum intact PTH.
Methods Participants A total of men and women were divided equally between 3 age groups years, years, and yearsidentified by a stratified, random selection process from the computerized population register of Reykjavik, the capital of Iceland, and invited to participate in our cross-sectional study on bone health. The recruitment period was from February to Januarywith an equal number of participants from each age group recruited monthly throughout the 2-year period to account for seasonal effects.
Does vitamin D affect calcium levels and the parathyroid glands?
The participants answered a detailed questionnaire on health-related issues, height and weight were measured, and body mass index BMI was calculated as weight in kilograms divided by the square of height in meters. The Icelandic Medical Ethics Committee approved the study, and all participants provided a written consent form. Dietary Assessment Vitamin D and calcium intake were assessed by using a self-administered, semi-quantitative food frequency questionnaire, which was developed by the Icelandic Nutrition Council.
It has been described and used in several studies and validated for foods and nutrients, including both calcium and vitamin D, and repeated hour recalls were used as the reference method.What is the Parathyroid Gland?
Interassay variations were 6. Interassay variation was 2.
Materials and Methods The present study is a descriptive cross-sectional study of data obtained through a databank from a clinical laboratory in Belo Horizonte, MG, Brazil. A total of 25 OH D tests results were collected between and Tests results from PTH measurements were also collected and analyzed. Samples were collected with a minimum eight hours fasting and vitamin D levels were obtained by quantitative determination of 25 OH D using automated competitive chemiluminescence immunoassay method Diasorin Liaison.
The reference values used in the present study were those determined by the clinical laboratory as follows: Data were expressed as mean, standard deviation, median, and percentiles.
Vitamin D Status and Its Association with Parathyroid Hormone Concentration in Brazilians
Statistical analysis was performed using Mann—Whitney and Spearman nonparametric test. Access to the clinical laboratory databank was previously authorized and the collected data were confidential.
No personal information was obtained. The study was submitted and approved by the ethics committee from Universidade Fumec, protocol number Results A total of laboratory test results were analyzed for 25 OH D levels.
It was possible to observe that the amount of serum 25 OH D tests performed by the clinical analysis laboratory increased during the period of this study. In the first year, tests were performed, compared to in the last year of the study data not shown. Data analysis also detected a value of The results were similar for each year analysis Table 1. Results for serum 25 OH D levels observed by analysis of a clinical laboratory databank.
Statistical analysis of 25 OH D values according to individuals age demonstrated that a negative correlation could be found between age and 25 OH D values. It was possible to note that The data suggest that vitamin D deficiency tends to increase with ageing. Percentage of vitamin D deficiency according to age group. Numbers in parenthesis show the exact percentage for each age group.
Parathyroid Glands: Vitamin D and calcium levels
A significant correlation was found between age and vitamin D deficiency. Analysis of 25 OH D measurements showed that Percentage of serum 25 OH D results according to reference values. These data suggest that individuals with vitamin D deficiency show high PTH values No significant differences were observed regarding the season when vitamin D was measured or the gender of the individuals.
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- Relationship Between Serum Parathyroid Hormone Levels, Vitamin D Sufficiency, and Calcium Intake
Parathyroid hormone concentrations according to vitamin D range. Discussion Vitamin D deficiency or insufficiency is currently an important nutritional and clinical concern all over the world, but there is still controversy about the optimal levels of serum 25 OH D for maintaining bone and muscle health. Over the last decade, there has been an increased interest in the role of vitamin D in health and diseases by the scientific community and by health professionals in general.
This seems to be due to a deeper understanding of the importance of vitamin D not only in bone metabolism, but also in other cell signaling processes and body functions such as immune, nervous, and cardiovascular systems [ 17 ].
Journal of Nutrition and Metabolism
Insufficient levels of vitamin D are being correlated to an increased risk of cardiovascular, autoimmune diseases, diabetes, respiratory diseases, obesity, and cancer [ 17 — 19 ]. One of the consequences of the increased interest in hypovitaminosis D is the large number of requests for laboratory evaluation of circulating vitamin D levels.
Similar results were observed in an Australian population, with an increased number of laboratory test performed between and These data are in accordance with the reference values found in the literature and to those we used in our study, further straightening the increased vitamin D deficiency in Brazilian individuals. Other studies performed in different countries also reinforce the crescent vitamin D deficiency, in both healthy and unhealthy people.
A recent study in Brazil also analyzed laboratory results and found similar values of serum 25 OH D Other studies also detected a high prevalence of vitamin D deficiency in other populations around the globe, including countries with a sunny environment [ 24 — 26 ]. Our study also detected that vitamin D deficiency seems to be related to the age of the individuals. The geriatric population is highly prone to develop alterations in the mechanisms of 25 OH D synthesis, due mainly to physiological changes related to the ageing process.
The present study showed significant vitamin D deficiency in 70 and older individuals. The high prevalence of hypovitaminosis D in the elderly could be associated with changes in mineral bone density, decreased sun exposure, and secondary hyperparathyroidism [ 15 ].